Allergy Clinical Data

ExACT Immunoplasty (Intralymphatic Immunotherapy)

2020 Intralymphatic Immunotherapy for Mountain Cedar Pollinosis

Our most recent study conducted by Aspire Allergy & Sinus' very own Dr. Chris Thompson and Dr. Stacy Silvers, with Dr. Mark Adam Shapiro

(ExACT) Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: A 3-year randomized placebo-controlled trial (Read the Study)

(ExACT) Intralymphatic Immunotherapy against grass pollen (Read the Study)

2008 ILIT Study

2012 Cat Study

2015 WHO Review

2016 Study

2017 Study Summary

2018 Study with dust, dog and cat

Hylander Grass Study

Why time interval between injections is essential

2019 cervical intralymphatic immunotherapy study for house dust mite allergic rhinitis

General Allergy Studies

Efficacy Studies - Prevention of Asthma In High-Risk Children
Download Study
History of Allergies May Be Associated with Increased Risk of High Blood Pressure, Heart Disease

Safety Studies

Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249

Safety of sublingual-swallow therapy in children and adults.
Intl Arch Allergy Immunol.
2000 Mar; 121(3):229-34
Review of 8 studies containing 690 patients. No serious reactions.

Grass pollen specific sublingual/swallow immunotherapy in children: open controlled comparison among different treatment protocols.
Allergologia et Immunopathogia
1999. 27(3): 145-51
268 children (age 2-15 years), approximately 96,000 doses of allergy drops
No serious or life-threatening reactions
Adverse events rate: 0.83 per 1000 doses (3% of children in the study)
7 adverse events requiring no treatment (including stomach pain, itchy eyes, nasal congestion)
1 case of hives which required treatment with an antihistamine

Safety of sublingual immunotherapy with monomeric allergoid in adults: multicenter post-marketing surveillance study.
198 patients, 32,800 doses of allergy drops
Adverse event rate was 0.52 per 1000 doses
Most required no treatment
Dose adjustment was needed in 4 patients (2 for stomach pain, 2 for hives)2 patients needed antihistamine (1 for hives, 1 for itchy eyes)

Efficacy of sublingual immunotherapy in asthma and eczema.
Chemical Immunology & Allergy, 2003. 82: 77-88.

344 children (age 5-12 years) undergoing allergy therapy for allergic asthma
No serious reactions
10% had an adverse reaction
Most common side effects were tiredness and/or headache
Most adverse events occurred during initial dose escalation
Wheezing in 2 patients (one was “mild”, the other was “moderate”)
Treatment stopped in 5 patients as a precaution (1 for nasal allergy symptoms, 2 for hives, 2 for wheezing)

Curr Med Res Opin.
Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections.

Effects of Allergies on Children

Seasonal allergens and performance in school

- Seasonal pollen allergies affect 1 in 5 school age children
- Allergies have a negative affect on children in school performance

Efficacy Studies

Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249

Sublingual immunotherapy: past, present, paradigm for the future? A review of the literature.
Otolayngol Head Neck Surg 2007; 136:S1-20
Review of 36 previous studies - 30 out of 36 studies showed efficacy in reduction of allergy symptoms, decrease in medication use or both. Efficacy shown for both seasonal and perennial allergens

Sublingual immunotherapy or allergic rhinitis: systematic review and meta-analysis.
Allergy 2005; 60: 4-12
Review of 22 previous double-blinded placebo controlled trials (adults and/or children)Significant reduction in symptom and medication scores
Efficacy clearly shown for combined ages and adults alone but not for children alone
Smaller number of studies evaluating children

Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3-18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials.
Annals All Asth Immunol. 97(2): 141-8, 2006 Aug.
10 previous studies of children receiving SLIT were reviewed
Significant improvement in symptom scores and medication scores
Subset analysis showed significant improvement for pollens only and for treatment duration of more than 18 months.Dust mites fell short of significance, but studies with higher doses did show significant improvement.

Sublingual immunotherapy for allergic rhinitis (including hay fever)
Cochrane Review February 2011.
Review of 60 previous studies
Significant improvement in symptom and medication in patients treated with sublingual drops
No serious adverse reactions

Sublingual immunotherapy (tablets, spray, or drops under the tongue) to treat inflammation of the conjunctiva due to allergy.
Cochrane Review July 2011.
Review of 42 previous studies
Sublingual therapy can reduce symptoms of allergic conjunctivitis (itchy/watery eyes)

Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites.
Mar;7(2):118-23. doi: 10.4168/aair.2015.7.2.118. Epub 2014 Oct 30.

Efficacy of sublingual specific immunotherapy in patients with respiratory allergy to Alternaria alternata: a randomized, assessor-blinded, patient-reported outcome, controlled 3-year trial.

Studies Comparing Allergy Drops to Allergy Shots

There have been a number of studies comparing allergy shots and drops. Some have shown that drops are better at treating nasal allergies, while others have shown that shots are better. Most have shown equal results between the two options. The opinion of Aspire Allergy & Sinus is that allergy shots and allergy drops have roughly the same effectiveness at treating allergies, and that allergy drops are safer than shots (though both are very safe if proper precautions are taken).

Here are a few references of studies comparing shots and drops:

Injective versus sublingual immunotherapy in Alternaria tenuis allergic patients

Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma--a placebo controlled study

Sublingual versus injective immunotherapy in grass pollen allergic patients: a double blind (double dummy) study