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Allergy Clinical Data

Safety Studies

Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
Article

Safety of sublingual-swallow therapy in children and adults.
Intl Arch Allergy Immunol.
2000 Mar; 121(3):229-34
Article
Review of 8 studies containing 690 patients. No serious reactions.

Grass pollen specific sublingual/swallow immunotherapy in children: open controlled comparison among different treatment protocols.
Allergologia et Immunopathogia
1999. 27(3): 145-51
Article
268 children (age 2-15 years), approximately 96,000 doses of allergy drops
No serious or life-threatening reactions
Adverse events rate: 0.83 per 1000 doses (3% of children in the study)
7 adverse events requiring no treatment (including stomach pain, itchy eyes, nasal congestion)
1 case of hives which required treatment with an antihistamine


Safety of sublingual immunotherapy with monomeric allergoid in adults: multicenter post-marketing surveillance study.
Article
198 patients, 32,800 doses of allergy drops
Adverse event rate was 0.52 per 1000 doses
Most required no treatment
Dose adjustment was needed in 4 patients (2 for stomach pain, 2 for hives)2 patients needed antihistamine (1 for hives, 1 for itchy eyes)


Efficacy of sublingual immunotherapy in asthma and eczema.
Chemical Immunology & Allergy, 2003. 82: 77-88.
http://www.ncbi.nlm.nih.gov/pubmed/12947994

344 children (age 5-12 years) undergoing allergy therapy for allergic asthma
No serious reactions
10% had an adverse reaction
Most common side effects were tiredness and/or headache
Most adverse events occurred during initial dose escalation
Wheezing in 2 patients (one was “mild”, the other was “moderate”)
Treatment stopped in 5 patients as a precaution (1 for nasal allergy symptoms, 2 for hives, 2 for wheezing)


Curr Med Res Opin.
Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections.
http://www.ncbi.nlm.nih.gov/pubmed/25753228#2015 Mar 31:1-3. [Epub ahead of print]

Effects of Allergies on Children

Seasonal allergens and performance in school

Highlights
- Seasonal pollen allergies affect 1 in 5 school age children
- Allergies have a negative affect on children in school performance

Efficacy Studies

Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and Guidelines.
Clinical and Experimental Otorhinolaryngology.
2014 Dec; 7(4): 241-249
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240478/pdf/ceo-7-241.pdf

Sublingual immunotherapy: past, present, paradigm for the future? A review of the literature.
Otolayngol Head Neck Surg 2007; 136:S1-20
http://www.ncbi.nlm.nih.gov/pubmed/17321336
Review of 36 previous studies30 out of 36 studies showed efficacy in reduction of allergy symptoms, decrease in medication use or both.Efficacy shown for both seasonal and perennial allergens

Sublingual immunotherapy or allergic rhinitis: systematic review and meta-analysis.
Allergy 2005; 60: 4-12
Article
Review of 22 previous double-blinded placebo controlled trials (adults and/or children)Significant reduction in symptom and medication scores
Efficacy clearly shown for combined ages and adults alone but not for children alone
Smaller number of studies evaluating children

Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3-18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials.
Annals All Asth Immunol. 97(2): 141-8, 2006 Aug.
Article
10 previous studies of children receiving SLIT were reviewed
Significant improvement in symptom scores and medication scores
Subset analysis showed significant improvement for pollens only and for treatment duration of more than 18 months.Dust mites fell short of significance, but studies with higher doses did show significant improvement.

Sublingual immunotherapy for allergic rhinitis (including hay fever)
Cochrane Review February 2011.
http://summaries.cochrane.org/CD002893/sublingual-immunotherapy-for-allergicrhinitis-including-hay-fever
Review of 60 previous studies
Significant improvement in symptom and medication in patients treated with sublingual drops
No serious adverse reactions

Sublingual immunotherapy (tablets, spray, or drops under the tongue) to treat inflammation of the conjunctiva due to allergy.
Cochrane Review July 2011.
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014569/
Review of 42 previous studiesSublingual therapy can reduce symptoms of allergic conjunctivitis (itchy/watery eyes)

Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites.
http://www.ncbi.nlm.nih.gov/pubmed/25729618# 2015
Mar;7(2):118-23. doi: 10.4168/aair.2015.7.2.118. Epub 2014 Oct 30.

Efficacy of sublingual specific immunotherapy in patients with respiratory allergy to Alternaria alternata: a randomised, assessor-blinded, patient-reported outcome, controlled 3-year trial.
https://www.ncbi.nlm.nih.gov/pubmed/21050060

Studies Comparing Allergy Drops to Allergy Shots

There have been a number of studies comparing allergy shots and drops. Some have shown that drops are better at treating nasal allergies, while others have shown that shots are better. Most have shown equal results between the two options. The opinion of Aspire Allergy & Sinus is that allergy shots and allergy drops have roughly the same effectiveness at treating allergies, and that allergy drops are safer than shots (though both are very safe if proper precautions are taken).

Here are a few references of studies comparing shots and drops:

http://www.ncbi.nlm.nih.gov/pubmed/8833170
http://www.ncbi.nlm.nih.gov/pubmed/10353581
http://www.ncbi.nlm.nih.gov/pubmed/8955574


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